Abstract
A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARalpha agonisim. As a result, highly potent, and selective PPARalpha agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.
MeSH terms
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Animals
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Carboxylic Acids / administration & dosage
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Carboxylic Acids / chemical synthesis
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Carboxylic Acids / pharmacology*
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Chromans / administration & dosage
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Chromans / chemical synthesis
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Chromans / pharmacology*
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Cricetinae
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Dogs
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Dose-Response Relationship, Drug
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Drug Design
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Drug Evaluation, Preclinical
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Humans
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Hypolipidemic Agents / administration & dosage
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Hypolipidemic Agents / chemical synthesis
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Hypolipidemic Agents / pharmacology*
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Macaca mulatta
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Male
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Molecular Structure
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PPAR alpha / agonists*
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Rats
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Rats, Sprague-Dawley
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Species Specificity
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Structure-Activity Relationship
Substances
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Carboxylic Acids
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Chromans
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Hypolipidemic Agents
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PPAR alpha